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Genome-wide comparison of DNA methylation patterns between yak and three cattle strains and their potential association with mRNA transcription

文献类型： 外文期刊

作者： Xin, Jin-Wei 1 ; Chai, Zhi-Xin 3 ; Jiang, Hui 1 ; Cao, Han-Wen 1 ; Chen, Xiao-Ying 1 ; Zhang, Cheng-Fu 1 ; Zhu, Yong 1 ; Zhang, Qiang 1 ; Ji, Qiu-Mei 2 ;

作者机构： 1.State Key Lab Hulless Barley & Yak Germplasm Reso, Lhasa 850000, Tibet, Peoples R China

2.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci & Vet, Minist Agr & Rural Affairs, Key Lab Anim Genet & Breeding Tibetan Plateau, Lhasa, Tibet, Peoples R China

3.Southwest Minzu Univ, Sichuan Prov & Minist Educ, Key Lab Qinghai Tibetan Plateau Anim Genet Resour, Chengdu, Sichuan, Peoples R China

关键词： adaptation; DNA methylation; high altitude; transcriptome; yak

期刊名称：JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION （ 影响因子：2.368； 五年影响因子：2.355 ）

ISSN： 1552-5007

年卷期：

页码：

收录情况： SCI

摘要： Yak has evolved specific adaptative mechanisms to high-altitude environment. Up to date, only a few studies reported the DNA methylation in yak. In the present study, genome-wide DNA methylome and transcriptome profiles in lung, mammary, and biceps brachii muscle tissues were compared between yak and three cattle breeds (Tibetan cattle, Sanjiang cattle, and Holstein cattle). The association between differentially expressed genes (DEGs) and differentially methylated regions (DMRs) was analyzed, and the biological functions of DEGs potentially driven by DMRs were explored by KEGG enrichment analysis. Finally, we found that yak-specific DMRs-driven DEGs were mainly involved in neuromodulation, respiration, lung development, blood pressure regulation, cardiovascular protection, energy metabolism, DNA repair, and immune functions. The higher levels of the key genes associated with these functions were observed in yak than in cattle, suggesting that DNA methylation might regulate these genes. Overall, the present study contributes basic data at the DNA methylation level to further understand the physiological metabolism in yak.

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