文献类型： 外文期刊
作者： Jiang, Hui 1 ; Chai, Zhi-Xin 3 ; Chen, Xiao-Ying 1 ; Zhang, Cheng-Fu 1 ; Zhu, Yong 1 ; Ji, Qiu-Mei 1 ; Xin, Jin-Wei 1 ;
作者机构： 1.State Key Lab Hulless Barley & Yak Germplasm Resou, Lhasa 850000, Tibet, Peoples R China
2.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci & Vet, Lhasa 850000, Tibet, Peoples R China
3.Southwest Minzu Univ, Key Lab Qinghai Tibetan Plateau Anim Genet Resourc, Sichuan Prov & Minist Educ, Chengdu 610041, Sichuan, Peoples R China
关键词： Yak; Genome; Database; Multi-omics; Plateau environment
期刊名称：BMC GENOMICS （ 影响因子：4.4； 五年影响因子：4.7 ）
ISSN： 1471-2164
年卷期： 2024 年 25 卷 1 期
页码：
收录情况： SCI
摘要： Background The yak (Bos grunniens) is a large ruminant species that lives in high-altitude regions and exhibits excellent adaptation to the plateau environments. To further understand the genetic characteristics and adaptive mechanisms of yak, we have developed a multi-omics database of yak including genome, transcriptome, proteome, and DNA methylation data.Description The Yak Genome Database (http://yakgenomics.com/) integrates the research results of genome, transcriptome, proteome, and DNA methylation, and provides an integrated platform for researchers to share and exchange omics data. The database contains 26,518 genes, 62 transcriptomes, 144,309 proteome spectra, and 22,478 methylation sites of yak. The genome module provides access to yak genome sequences, gene annotations and variant information. The transcriptome module offers transcriptome data from various tissues of yak and cattle strains at different developmental stages. The proteome module presents protein profiles from diverse yak organs. Additionally, the DNA methylation module shows the DNA methylation information at each base of the whole genome. Functions of data downloading and browsing, functional gene exploration, and experimental practice were available for the database.Conclusion This comprehensive database provides a valuable resource for further investigations on development, molecular mechanisms underlying high-altitude adaptation, and molecular breeding of yak.
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