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Gelatinase MMP Expression Is Correlated with Muscle Fiber Growth in Maiwa Yak Gluteus Maximus

文献类型： 外文期刊

作者： Yang, Huan 1 ; Ouyang, Tanliang 1 ; Chai, Zhixin 1 ; Jiang, Hui 2 ; Zhao, Hongwen 4 ; Ma, Zongliang 1 ; Zhong, Jincheng 1 ; Wang, Jiabo 1 ; Zhang, Ming 1 ; Wu, Zhijuan 1 ; Xin, Jinwei 2 ;

作者机构： 1.Southwest Minzu Univ, Qinghai Tibetan Plateau Anim Genet Resource Reserv, Chengdu 610225, Qinghai, Peoples R China

2.State Key Lab Hulless Barley & Yak Germplasm Resou, Lhasa 850000, Xizang, Peoples R China

3.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci & Vet, Key Lab Anim Genet & Breeding Tibetan Plateau, Minist Agr & Rural Affairs, Lhasa 850009, Xizang, Peoples R China

4.Sichuan Acad Grassland Sci, Chengdu 611731, Peoples R China

关键词： Yak; Matrix metalloproteinases; MMP-2; MMP-9; Muscle fibers

期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH （ 影响因子：3.6； 五年影响因子：3.8 ）

ISSN： 0163-4984

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Yak (Bos grunniens) is the only large mammal species in the Qinghai-Tibet Plateau. The most of the studies in yak remain confined for the main contributor of meat, which requires a good understanding of muscle growth. Matrix metalloproteinases-2 (MMP-2) and MMP-9 are widely expressed in mammal tissues they mainly degrade collagen in the extracellular matrix for muscle development. However, the influence of MMPs on yak muscle remains unclear. Hence, we assessed the expression of MMP-2, MMP-9, and related factors with ages in Maiwa yak for study the correlation between MMPs expression and yak muscle growth. The mRNA expression of MMP-2, MMP-9, MMP-14, and collagen III increased with age, except collagen I by quantitative real-time PCR. Moreover, muscle fiber diameter increased with age, whereas the density decreased, which showed that fiber grew thicker with age using hematoxylin-eosin staining. Interestingly, MMP and collagen expression significantly decreased with age using western blotting. Pearson correlation method showed that both mRNA and protein expression of MMP-14 and collagen were strongly correlated with muscle fiber growth, but MMP-2 protein and MMP-9 mRNA expression were moderately correlated with muscle fiber growth. Overall, the expression of MMPs and collagen significantly changed with age, which means that MMPs and their function related genes could correlate with Maiwa yak muscle fiber growth.

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