文献类型： 外文期刊
作者： Chen, Hongyu 1 ; Zhang, Jinjin 1 ; Ren, Jinwei 1 ; Wang, Wenzhao 1 ; Xiong, Weiping 3 ; Zhang, Yaodong 4 ; Bao, Li 1 ; Liu, Hongwei 1 ;
作者机构： 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, 1 Beichenxi Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China
3.Tibet Acad Agr & Anim Sci, Inst Vegetable Res, 157 Jinzhuxi Rd, Lhasa 850000, Peoples R China
4.Tibet Lingzhi Biotech Co Ltd, Econ & Hitech Dev Area, 15 Galsang Rd, Lhasa 850000, Peoples R China
关键词： Ganoderma leucocontextum; neuroprotective effects; triterpene
期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.745； 五年影响因子：2.581 ）
ISSN： 1612-1872
年卷期： 2018 年 15 卷 5 期
页码：
收录情况： SCI
摘要： Ganoderma leucocontextum is a well-known medicinal mushroom cultivated in the Tibet Plateau of China. Chemistry investigation on the fruiting bodies of this mushroom resulted in the isolation of sixteen secondary metabolites including three new lanostane triterpenes, ganoleucoins Q - S (1 - 3), as well as thirteen known compounds (4 - 16). The structures of compounds 1 - 3 were determined by NMR, MS, CD spectral analysis, and chemical derivation method. The neuroprotective effects of compounds 1 - 16 were tested on PC12 cells. Compounds 1 and 2 showed protective effects against the H2O2 induced damage with the survival rate of 83.19 +/- 0.92%, 73.37 +/- 1.25% at the concentration of 200 m, respectively. Meanwhile, compounds 1 and 2 induced neurite outgrowth at 50 - 200 m. The results from this study suggested that G. leucocontextum and its metabolites may be potential functional food ingredients for the prevention of neurodegenerative diseases.
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