Eight new triterpenoids with inhibitory activity against HMG-CoA reductase from the medical mushroom Ganoderma leucocontextum collected in Tibetan plateau
文献类型： 外文期刊
作者： Zhang, Jinjin 1 ; Ma, Ke 1 ; Han, Junjie 1 ; Wang, Kai 1 ; Chen, Hongyu 1 ; Bao, Li 1 ; Liu, Li 1 ; Xiong, Weiping 3 ; Zhang, Yaodong 4 ; Huang, Ying 5 ; Liu, Hongwei 1 ;
作者机构： 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China
3.Tibet Acad Agr & Anim Sci, Inst Vegetable Res, Lhasa, Peoples R China
4.Tibet Lingzhi Biotech Co Ltd, Econ & Hitech Dev Area, 15 Galsang Rd, Lhasa, Peoples R China
5.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing, Peoples R China
关键词： Ganoderma leucocontextum; Triterpenoids; HMG-CoA reductase inhibitor; Structure-activity relationship
期刊名称：FITOTERAPIA （ 影响因子：3.204； 五年影响因子：3.297 ）
ISSN： 0367-326X
年卷期： 2018 年 130 卷
页码：
收录情况： SCI
摘要： Eight new triterpenoids, ganoleucoins T-Z(1-3, 5-8), and AA (9), together with eleven known triterpenes were isolated and identified from the wild fruiting bodies of the medicinal mushroom Ganoderma leucocontextum. The structures of new compounds were determined on the basis of NMR and MS spectral analysis. The inhibitory effects of 1-9 on HMG-CoA reductase were tested in vitro. Compounds 1, 7 and 8 showed significant HMG-CoA reductase inhibition with IC50 values of 10.2, 9.72 and 8.68 mu M, respectively. The other isolated compounds presented relatively weak inhibitory activity with IC50 values > 100 mu M. Preliminary structure-activity relationship analysis showed that the HMG moiety in 7 and 8 contributed greatly to their inhibitory activity against HMG-CoA reductase. This work further demonstrates the mushroom G. leucocontextum to be valuable herbal medicine that deserves deep investigation.
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