Gut microbiome-based therapies for alleviating cognitive impairment: state of the field, limitations, and future perspectives
文献类型： 外文期刊
作者： Bu, Linli 1 ; Wang, Chen 1 ; Bai, Junying 2 ; Song, Jiajia 1 ; Zhang, Yuhong 3 ; Chen, Hongyu 1 ; Suo, Huayi 1 ;
作者机构： 1.Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China
2.Southwest Univ, Citrus Res Inst, Chongqing 400715, Peoples R China
3.Tibet Acad Agr & Anim Husb Sci, Inst Food Sci & Technol, Xizang 850000, Peoples R China
4.Modern Chuan Cai Yu Wei Food Ind Innovat Res Inst, Chongqing 400715, Peoples R China
期刊名称：FOOD & FUNCTION （ 影响因子：6.1； 五年影响因子：6.5 ）
ISSN： 2042-6496
年卷期： 2024 年 15 卷 3 期
页码：
收录情况： SCI
摘要： Cognitive impairment (CI) is a multifaceted neurological condition that can trigger negative emotions and a range of concurrent symptoms, imposing significant public health and economic burdens on society. Therefore, it is imperative to discover a remedy for CI. Nevertheless, the mechanisms behind the onset of this disease are multifactorial, which makes the search for effective amelioration difficult and complex, hindering the search for effective measures. Intriguingly, preclinical research indicates that gut microbiota by influencing brain function, plays an important role in the progression of CI. Furthermore, numerous preclinical studies have highlighted the potential of probiotics, prebiotics, fecal microbiota transplantation (FMT), and diet in modulating the gut microbiota, thereby ameliorating CI symptoms. This review provides a comprehensive evaluation of CI pathogenesis, emphasizing the contribution of gut microbiota disorders to CI development. It also summarizes and discusses current strategies and mechanisms centered on the synergistic role of gut microbiota modulation in the microbiota-gut-brain axis in CI development. Finally, problems with existing approaches are contemplated and the development of microbial modulation strategies as therapeutic approaches to promote and restore brain cognition is discussed. Further research considerations and directions are highlighted to provide ideas for future CI prevention and treatment strategies. Cognitive impairment (CI) is a multifaceted neurological condition that can trigger negative emotions and a range of concurrent symptoms, imposing significant public health and economic burdens on society.
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