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Differences in proteomic profiles between yak and three cattle strains provide insights into molecular mechanisms underlying high-altitude adaptation

文献类型： 外文期刊

作者： Xin, Jin-Wei 1 ; Chai, Zhi-Xin 3 ; Zhang, Cheng-Fu 1 ; Zhang, Qiang 1 ; Zhu, Yong 1 ; Cao, Han-Wen 1 ; YangJi, Cidan 1 ;

作者机构： 1.State Key Lab Hulless Barley & Yak Germplasm Reso, Lhasa, Ghana

2.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci & Vet, Lhasa, Peoples R China

3.Southwest Minzu Univ, Key Lab Qinghai Tibetan Plateau Anim Genet Resour, Sichuan Prov & Minist Educ, Chengdu, Peoples R China

关键词： cardiac muscle contraction; high-altitude adaptation; retinol metabolism; toll-like receptor; yak

期刊名称：JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION （ 影响因子：2.13； 五年影响因子：2.322 ）

ISSN： 0931-2439

年卷期：

页码：

收录情况： SCI

摘要： Yaks display unique properties of the lung and heart, enabling their adaptation to high-altitude environments, but the underlying molecular mechanisms are still largely unknown. In the present study, the proteome differences in lung and heart tissues were compared between yak (Bos grunniens) and three cattle strains (Bos taurus, Holstein, Sanjiang and Tibetan cattle) using the sequential window acquisition of all theoretical mass spectra/data-independent acquisition (SWATH/DIA) proteomic method. In total, 51,755 peptides and 7215 proteins were identified. In the lung tissue, there were 162, 310 and 118 differential abundance proteins (DAPs) in Tibetan, Holstein and Sanjiang cattle compared to yak respectively. In the heart tissue, there were 71, 57 and 78 DAPs in Tibetan, Holstein and Sanjiang cattle compared to yak respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that the DAPs were enriched for the retinol metabolism and toll-like receptor categories in lung tissue. The changes in these two pathways may regulate hypoxia-induced factor and immune function in yaks. Moreover, DAPs in heart tissues were enriched for cardiac muscle contraction, Huntington's disease, chemical carcinogenesis and drug metabolism-cytochrome P450. Further exploration indicated that yaks may alter cardiac function through regulation of type 2 ryanodine receptor (RyR2) and Ca2+-release channels. The present results are useful to further develop an understanding of the mechanisms underlying adaptation of animals to high-altitude conditions.

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