Antibacterial mechanism of vitamin C against Staphylococcus aureus, reduction of toxicity of metabolites and its application in pasteurized milk
文献类型： 外文期刊
作者： Tian, Lei 1 ; Huang, Chunyang 1 ; Liu, Xing 1 ; Zhang, Yuxin 1 ; Zhou, Ting 2 ; Yu, Ying 3 ; Zhang, Chunling 1 ; Pan, Hu 4 ; Dai, Yanna 4 ; Pu, Jifeng 4 ; Fu, Chengyu 5 ; Zhang, Pengfei 5 ; Wang, Xin 1 ;
作者机构： 1.Northwest A&F Univ, Coll Food Sci & Engn, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
2.Northwest A&F Univ, Coll Vet Med, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
3.China Agr Univ, Coll Anim Sci & Technol, Key Lab Agr Anim Genet & Breeding, Natl Engn Lab Anim Breeding,Minist Agr, 2 Yuanmingyuan Garden West Rd, Beijing 100193, Peoples R China
4.Tibet Acad Agr & Anim Husb Sci, Inst Agr Qual Stand & Testing, 130 Jinzhu West Rd, Lhasa 850032, Tibet, Peoples R China
5.Xian Polytech Univ, Sch Text Sci & Engn, 19 Jinhua Rd, Xian 710048, Shaanxi, Peoples R China
关键词： Vitamin C; Staphylococcus aureus; Antibacterial mechanism; Pasteurized milk
期刊名称：INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：5.3 ）
ISSN： 0168-1605
年卷期： 2026 年 445 卷
页码：
收录情况： SCI
摘要： This study explored the antibacterial mechanism of Vitamin C (VC) against Staphylococcus aureus (S. aureus), reduction of toxicity of metabolites and its potential applications in pasteurized milk. VC inhibits the growth of S. aureus by damaging the cell wall, reducing intracellular ATP levels, inducing membrane depolarization, compromising membrane integrity, and altering cell morphology. The leakage of nucleic acids and proteins further indicates that VC disrupts the cell membrane. Electrophoretic analysis revealed that high concentrations of VC degrade genomic DNA and proteins. Crystal violet staining confirmed that VC inhibits biofilm formation. Real-time quantitative PCR analysis revealed that subinhibitory concentrations of VC modulated quorum sensing, virulence gene expression, adhesion, and global regulatory gene expression in S. aureus (P < 0.05). Hemolysis assays, Western blotting, and skin infection tests demonstrated that VC reduces the toxicity of S. aureus metabolites. Additionally, VC exhibited antibacterial effects in pasteurized milk, suggesting its potential as a natural preservative.
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