Liver Transcriptome Analysis Reveals the Mechanisms of Metabolic Adaptation of Xizang Sheep to Seasonal Changes
文献类型： 外文期刊
作者： Cui, Jianzhao 1 ; Pan, Junru 4 ; Sun, Fengbo 5 ; Zhang, Nan 5 ; Jinmei, Jiacuo 5 ; Zhen, Yang 5 ; Puchi, Ciren 6 ; Snag, Luo 6 ; Liu, Zengqiang 1 ; Zhao, Wangsheng 4 ; Zhaxi, Yangzong 1 ;
作者机构： 1.Xizang Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa 850009, Peoples R China
2.Shigatse Sci & Technol Bur, Shigatse 857000, Peoples R China
3.Minist Agr & Rural Affairs, Key Lab Anim Genet & Breeding Xizang Plateau, Lhasa 850009, Peoples R China
4.Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621000, Peoples R China
5.Xizang Autonomous Reg Ctr Dis Control & Prevent, Lhasa 850009, Peoples R China
6.Agr & Rural Bur Jiangzi Cty, Nanchang 857400, Jiangzi, Peoples R China
关键词： Xizang sheep; liver; seasonal changes; transcriptome; metabolic adaptation
期刊名称：METABOLITES （ 影响因子：3.7； 五年影响因子：4.1 ）
ISSN：
年卷期： 2024 年 14 卷 11 期
页码：
收录情况： SCI
摘要： Background/Objectives: The Xizang sheep is a unique breed of sheep in the highland regions of China that has gradually developed physiological characteristics adapted to the plate environment through long-term natural selection and artificial breeding. However, little is known about the molecular basis of metabolic adaptation to seasons in Xizang sheep. Methods: In this study, liver tissues from Xizang sheep in summer (SL) and autumn (AL) were selected for transcriptome sequencing to explore the metabolic adaptability of Xizang sheep to seasons. Results: The results showed that a total of 12,046 differentially expressed genes (DEGs) were identified, with 1123 genes significantly upregulated and 951 genes significantly downregulated in autumn. The top five pathways enriched for DEGs were Metabolic pathways, Phagosome, Valine, leucine and isoleucine degradation, Propanoate metabolism, and Fatty acid metabolism, which are involved in immune regulation, fat oxidation, and synthesis. The reduction in lipid synthesis, fatty acid oxidation, and fat breakdown metabolism promotes gluconeogenesis by inhibiting the Peroxisome proliferator-activated receptors (PPAR) and Phosphoinositide 3-kinase- Protein kinase B (PI3K-Akt) signaling pathways. Conclusions: This process helps to maintain the whole-body energy homeostasis of Xizang sheep, facilitating their adaptation to the seasonal changes in the extreme high-altitude environment. These findings provide foundational data for studying the molecular mechanisms of metabolic adaptation to seasons in ruminants.
- 相关文献
作者其他论文 更多>>
-
Multi-omics analysis of the mechanism of alfalfa and wheat-induced rumen flatulence in Xizang sheep
作者：Wu, Jing;Zhang, Xiaoming;Cui, Jianzhao;Zhaxi, Yangzong;Li, Long;Song, Tianzeng;Wu, Jing;Zhang, Xiaoming;Ayesha, Khan;Zhao, Wangsheng;Song, Tianzeng;Khuram, Shahzad;Cui, Jianzhao;Wang, Gaofu;Shi, Mingyan;Jiang, Xunping;Liu, Guiqiong;Song, Tianzeng
关键词：rumen flatulence; rumen microorganisms; Xizang sheep; alfalfa; wheat
-
Integrative multi-omics analysis reveals liver-gut axis adaptation in high-altitude goats
作者：Li, Haiyan;Zhang, Xin;Pan, Cheng;Zhang, Zhenzhen;Pan, Junru;Zhao, Wangsheng;Li, Haiyan;Zhaxi, Yangzong;Song, Tianzeng;Zhaxi, Yangzong;Song, Tianzeng;Shahzad, Khuram;Sun, Fengbo;Zhen, Yang;Jinmei, Jiacuo
关键词：Goat; Gut microbiota; Liver-gut axis; Plateau adaptation
-
Rumen microbiota regulates IMF deposition in Xizang sheep by activating the PPARγ transcription factor: a rumen-muscle axis perspective
作者：Pan, Cheng;Pan, Junru;Li, Haiyan;Zhang, Zhenzhen;Zhao, Wangsheng;Zhaxi, Yangzong;Song, Tianzeng;Zhaxi, Yangzong;Song, Tianzeng;Guan, Feng;Jinmei, Jiacuo;Baijiu, Zhaxi;Yixi, Quzhu;Baima, Sangzhu
关键词：Xizang sheep; meat flavor; IMF; rumen-muscle axis; multi-omics
-
The impact of GnRH immunocastration on colonic microbiota and metabolites in male sheep
作者：Mustafa, Shehr Bano;Zhang, Xiaoming;Wu, Jing;Zhao, Wangsheng;Long, Hua;Song, Tianzeng;Zhaxi, Yangzong;Chen, Xiaoying;Song, Tianzeng;Jiang, Xunping;Liu, Guiqiong;Shahzad, Khuram;Zeng, Xianyin
关键词：colonic; GnRH immunocastration; metabolomic; microbiome; sheep; surgical castration; testosterone;
16S rRNA sequencing -
Sulforaphane reduces adipose tissue fibrosis via promoting M2 macrophages polarization in HFD fed-mice
作者：Zhang, Zhenzhen;Chen, Huali;Pan, Cheng;Li, Rui;Zhao, Wangsheng;Zhang, Zhenzhen;Song, Tianzeng
关键词：Adipose tissue fibrosis; Obesity; Sulforaphane; Macrophages polarization; Nuclear factor E2-related factor 2; Metabolic disorders
-
The expression spectrum of yak epididymal epithelial cells reveals the functional diversity of caput, corpus and cauda regions
作者：Pan, Meilan;Luo, Xiaofeng;Zhang, Zhenzhen;Li, Jingjing;Zhao, Wangsheng;Shahzad, Khuram;Danba, Zhaxi;Chilie, Wangmu;Caiwang, Gongbu;Chen, Xiaoying
关键词：Epididymis epithelial cells; RNA-Seq; Differential gene expression
-
GnRH Immunocastration in Male Xizang Sheep: Impacts on Rumen Microbiome and Metabolite Profiles for Enhanced Health and Productivity
作者：Zhang, Xiaoming;Song, Tianzeng;Zhaxi, Yangzong;Chen, Xiaoying;Zhang, Xiaoming;Wu, Jing;Mustafa, Shehr Bano;Zhao, Wangsheng;Song, Tianzeng;Liu, Guiqiong;Jiang, Xunping;Shahzad, Khuram
关键词：male Xizang sheep; GnRH immunocastration; rumen; microorganisms
