Sulforaphane reduces adipose tissue fibrosis via promoting M2 macrophages polarization in HFD fed-mice
文献类型： 外文期刊
作者： Zhang, Zhenzhen 1 ; Chen, Huali 1 ; Pan, Cheng 1 ; Li, Rui 1 ; Zhao, Wangsheng 1 ; Song, Tianzeng 3 ;
作者机构： 1.Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621010, Sichuan, Peoples R China
2.Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key L, Chengdu 611130, Sichuan, Peoples R China
3.Inst Anim Sci, Tibet Acad Agr & Anim Husb Sci, Lhasa 850009, Peoples R China
关键词： Adipose tissue fibrosis; Obesity; Sulforaphane; Macrophages polarization; Nuclear factor E2-related factor 2; Metabolic disorders
期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH （ 影响因子：5.1； 五年影响因子：5.3 ）
ISSN： 0167-4889
年卷期： 2024 年 1871 卷 2 期
页码：
收录情况： SCI
摘要： Adipose tissue fibrosis has been identified as a novel contributor to the pathomechanism of obesity associated metabolic disorders. Sulforaphane (SFN) has been shown to have an anti-obesity effect. However, the impact of SFN on adipose tissue fibrosis is still not well understood. In this study, obese mice induced by high-fat diets (HFD) were used to examine the effects of SFN on adipose tissue fibrosis. According to the current findings, SFN dramatically enhanced glucose tolerance and decreased body weight in diet-induced-obesity (DIO) mice. Additionally, SFN therapy significantly reduced extracellular matrix (ECM) deposition and altered the expression of genes related to fibrosis. Furthermore, SFN also reduced inflammation and promoted macrophages polarization towards to M2 phenotype in adipose tissue, which protected adipose tissue from fibrosis. Notably, SFNmediated nuclear factor E2-related factor 2 (Nrf2) activation was crucial in decreasing adipose tissue fibrosis. These results implied that SFN had favorable benefits in adipose tissue fibrosis, which consequently ameliorates obesity-related metabolic problems. Our research provides new treatment strategies for obesity and associated metabolic disorders.
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