Lactobacillus pentosus LPQ1 attenuates depressive-like behavior in BALB/C mice induced by chronic unpredictable mild stress (CUMS)
文献类型： 外文期刊
作者： Zeng, Yixiu 1 ; Wei, Zhen 3 ; Zhang, Yuhong 4 ; Zhang, Feng 5 ; Song, Jiajia 1 ; Suo, Huayi 1 ;
作者机构： 1.Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China
2.Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510080, Peoples R China
3.Chinese Acad Agr Sci, Inst Food Sci & Technol CAAS, Nutr & Funct Food Innovat Ctr, Beijing 100193, Peoples R China
4.Tibet Acad Agr & Anim Husb Sci, Inst Food Sci & Technol, Lhasa 850000, Peoples R China
5.Chongqing Tianyou Dairy Co Ltd, Chongqing 401120, Peoples R China
关键词： Lactobacillus pentosus LPQ1; 5-Hydroxytryptophan; Depression; Chronic unpredictable mild stress
期刊名称：FOOD BIOSCIENCE （ 影响因子：5.9； 五年影响因子：6.1 ）
ISSN： 2212-4292
年卷期： 2024 年 62 卷
页码：
收录情况： SCI
摘要： The development of depression is directly correlated with the concentration of 5-hydroxytryptophan (5-HTP). It has been demonstrated that Lactobacillus increases 5-HTP secretion, however, it is unclear how this elevated 5HTP secretion results in antidepressant benefits. Mice exposed to chronic unpredictable mild stress (CUMS) were administered L. pentosus LPQ1 by gavage for 35 days. According to our findings, CUMS-exposed mice showed an improvement in body weight when treated with L. pentosus LPQ1. Furthermore, we discovered that in mice given CUMS, L. pentosus LPQ1 raised neurotransmitter levels and decreased behavior resembling depression. Also, L. pentosus LPQ1 upregulated hippocampal 5-HT1A, phosphorylated cyclic adenosine monophosphate responsive element binding protein (p-CREB)/CREB, brain-derived neurotrophic factor (BDNF), and phosphorylated tropomyosin kinase B (p-Tr kappa B/Tr kappa B) kappa B/Tr kappa B) expression of CUMS-exposed mice. Additionally, L. pentosus LPQ1 is associated with an increase in the number of helpful bacteria in the gut microbiota, including Unclassified-f-Lach- Lach- nospiracea, , Lachnospiraceae-NK4A136-group,-NK4A136- group, Eubacterium_xylanophilum_group. group. In summary, L. pentosus LPQ1 attenuated CUMS-induced depression by restoring 5-HTP-related 5-HT1A-CREB-BDNF-Tr kappa B kappa B signaling. Interestingly, the improvement of depressive-like behavior by L. pentosus LPQ1 is also related to the improvement of gut microbiota dysbiosis. According to our research, L. pentosus LPQ1 may be a useful therapeutic alternative for depressed people.
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