Refined highland barley ameliorates obesity-associated insulin resistance in high-fat diet-fed mice by targeting the gut microbiota and liver transcriptomics
文献类型： 外文期刊
作者： Wu, Tong 1 ; Dai, Zijian 1 ; Luo, Yingting 1 ; Yu, Qinye 1 ; Zhang, Yiyun 1 ; Bao, Xin 1 ; Li, Rong 1 ; Zhang, Yuhong 3 ; Hao, Jing 4 ; Shen, Qun 1 ; Xue, Yong 1 ;
作者机构： 1.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
2.China Agr Univ, Natl Ctr Technol Innovat Food Ind, Beijing 100083, Peoples R China
3.Tibet Acad Agr & Anim Sci, Lhasa 850002, Peoples R China
4.Qinghai Tianyoude Technol Investment Management Gr, Xining 810500, Qinghai, Peoples R China
5.Qinghai Engn Technol Res Inst Comprehens Utilizat, Qinghai 810016, Qinghai, Peoples R China
关键词： Refined highland barley; Inflammation; Hypoglycemic effect; Gut microbiota; Liver transcriptome
期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：4.3； 五年影响因子：4.7 ）
ISSN： 1436-6207
年卷期： 2025 年 64 卷 2 期
页码：
收录情况： SCI
摘要： PurposeIt is generally believed that refined grains lack nutritional value compared to whole grains. The objective of this study was to investigate whether refined highland barley (RHB) holds the potential to combat obesity-associated insulin resistance.MethodsThirty-two male 6-week-old C57BL/6J mice were randomly divided into four groups fed with a normal chow diet, a high-fat diet (HFD), a 30% RHB supplemented HFD diet, and a 30% whole-grain highland barley (WGHB) supplemented HFD diet. We examined the anti-obesity and anti-insulin resistance effects of RHB and compared them with WGHB in mice.ResultsRHB intervention effectively improved obesity and insulin resistance, enhanced the intestinal mucosal barrier, and reduced inflammation. Moreover, it promoted the abundance of beneficial gut bacteria such as Akkermansia, Bifidobacterium, Lachnospiraceae_NK4A136_group, Lachnospiraceae_UCG-001, Alloprevotella, and increased the production of short-chain fatty acids (SCFAs) in faeces. Additionally, RHB intervention modulated liver gene transcription, downregulating inflammatory genes like IRF3/7, STAT1/2, NLRP3, and TLR2.ConclusionsRHB could effectively alleviate obesity-related insulin resistance by targeting gut microbiota and liver transcriptomics, and its beneficial impacts are comparable to those of WGHB.
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