Whole-Grain Highland Barley Attenuates Atherosclerosis Associated with NLRP3 Inflammasome Pathway and Gut Microbiota in ApoE-/- Mice
文献类型： 外文期刊
作者： Wu, Tong 1 ; Yu, Qinye 1 ; Luo, Yingting 1 ; Dai, Zijian 1 ; Zhang, Yuhong 3 ; Wang, Chao 1 ; Shen, Qun 1 ; Xue, Yong 1 ;
作者机构： 1.China Agr Univ, Coll Food Sci & Nutr Engn, Natl Engn & Technol Res Ctr Fruits & Vegetables, Beijing 100083, Peoples R China
2.Natl Ctr Technol Innovat Deep Proc Highland Barley, Beijing 100083, Peoples R China
3.Tibet Acad Agr & Anim Husb Sci, Lhasa 850000, Peoples R China
关键词： highland barley; ApoE(-/-) mice; atherosclerosis; NLRP3 inflammasome pathway; gut microbiota
期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）
ISSN：
年卷期： 2023 年 15 卷 19 期
页码：
收录情况： SCI
摘要： The efficacy and mechanism of highland barley in the treatment of atherosclerosis have received little attention. Herein, we aimed to explore whether highland barley supplementation can prevent atherosclerosis progression and improve gut microbiota disorder in apolipoprotein E knockout (ApoE-/-) mice. Male ApoE-/- mice were fed a high-fat diet with whole-grain highland barley (WHB) or refined highland barley for 18 weeks. WHB substantially inhibited the formation of atherosclerotic plaques, reduced serum tumor necrosis factor-alpha, and downregulated the expression of NLRP3 in the aorta. Furthermore, the 16S rRNA analysis revealed that highland barley supplementation helped to restore the dysregulation of the gut microbiota, as evidenced by an increase in the relative abundance of specific beneficial bacteria known for their anti-inflammatory properties, such as Lachnospiraceae, Lactobacillus, Muribaculaceae, and Bifidobacterium. Highland barley supplementation might alleviate atherosclerotic plaque formation by modulating the NLRP3 inflammasome pathway and the synthesis of anti-inflammatory metabolites by the gut microbiota.
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