文献类型： 外文期刊
作者： Zhang, Guoqiang 1 ; Yu, Dailin 3 ; Sang, Bu 3 ; Feng, Juntao 1 ; Han, Lirong 1 ; Zhang, Xing 1 ;
作者机构： 1.Northwest A&F Univ, Res & Dev Ctr Biorat Pesticide, Yangling 712100, Shaanxi, Peoples R China
2.Shihezi Univ, Coll Agr, Shihezi 832000, Xinjiang, Peoples R China
3.Tibet Acad Agr & Anim Husb Sci, Agr Res Inst, Lhasa 850032, Tibet, Peoples R China
关键词： genome mining;secondary metabolism;nsdA;regulator;glycoprotein GP-1
期刊名称：GENES （ 影响因子：4.096； 五年影响因子：4.339 ）
ISSN： 2073-4425
年卷期： 2017 年 8 卷 12 期
页码：
收录情况： SCI
摘要： Streptomyces kanasensis ZX01 produces some antibiotics and a glycoprotein with antiviral activity. To further evaluate its biosynthetic potential, here we sequenced the 7,026,279 bp draft genome of S. kanasensis ZX01 and analyzed all identifiable secondary gene clusters for controlling natural products. More than 60 putative clusters were found in S. kanasensis ZX01, the majority of these biosynthetic loci are novel. In addition, the regulators for secondary metabolism in S. kanasensis ZX01 were abundant. The global regulator nsdA not only controls biosynthesis of some antibiotics, but also enhances production of glycoprotein GP-1 with antiviral activity. This study importantly reveals the powerful interplay between genomic analysis and studies of traditional natural product purification/production increasing.
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