Differential gene expression and gut microbiota composition in low-altitude and high-altitude goats
文献类型： 外文期刊
作者： Zhang, Zhenzhen 1 ; Zhang, Xin 1 ; Zhang, Tingting 2 ; Li, Jingjing 1 ; Renqing, Cuomu 3 ; Baijiu, Zhaxi 5 ; Baima, Sangzhu 6 ; Zhaxi, Wangjie 6 ; Nima, Yuzhen 6 ; Zhao, Wangsheng 1 ; Song, Tianzeng 3 ;
作者机构： 1.Southwest Univ Sci & Technol, Coll Life Sci & Engn, Mianyang 621000, Sichuan, Peoples R China
2.Southwest Univ Sci & Technol, Key Discipline Lab Natl Def Nucl Waste & Environm, Mianyang 621000, Sichuan, Peoples R China
3.Xizang Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa 850009, Xizang, Peoples R China
4.Minist Agr & Rural Affairs, Key Lab Anim Genet & Breeding Xizang Plateau, Lhasa 850009, Xizang, Peoples R China
5.Cultural Serv Ctr Maqian Township, Nagqu 852599, Xizang, Peoples R China
6.Husb Tech Baingoin Cty, Serv Stn Agr & Anim, Nagqu 852599, Xizang, Peoples R China
关键词： Goat; Altitude; Gut microbiota; Testis; Reproductive fitness; Synergistic role
期刊名称：GENOMICS （ 影响因子：3.0； 五年影响因子：3.3 ）
ISSN： 0888-7543
年卷期： 2024 年 116 卷 5 期
页码：
收录情况： SCI
摘要： Previous studies have presented evidence suggesting that altitude exerts detrimental effects on reproductive processes, yet the underlying mechanism remains elusive. Our study employed two distinct goat breeds inhabiting low and high altitudes, and conducted a comparative analysis of mRNA profiles in testis tissues and the composition of gut microbiota. The results revealed a reduced testis size in high-altitude goats. RNA-seq analysis identified the presence of 214 differentially expressed genes (DEGs) in the testis. These DEGs resulted in a weakened immunosuppressive effect, ultimately impairing spermatogenesis in high-altitude goats. Additionally, 16S rDNA amplicon sequencing recognized statistically significant variations in the abundance of the genera Treponema, unidentified_Oscillospiraceae, Desulfovibrio, Butyricicoccus, Dorea, Parabacteroides between the two groups. The collective evidence demonstrated the gut and testis played a synergistic role in causing decreased fertility at high altitudes. Our research provides a theoretical basis for future investigations into the reproductive fitness of male goats.
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