Active immunization against gonadotropin-releasing hormone enhances the generation of B cells but does not affect their colonization in peripheral immune organs in male rats
文献类型： 外文期刊
作者： Li, Dong 1 ; Yao, Huan 1 ; Cao, Xiaohan 1 ; Han, Xingfa 1 ; Song, Tianzeng 2 ; Zeng, Xianyin 1 ;
作者机构： 1.Sichuan Agr Univ, Coll Life Sci, Yaan 625014, Sichuan, Peoples R China
2.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa 850009, Xizang, Peoples R China
关键词： GnRH immunization; B cell; Generation; Apoptosis; Cell cycle
期刊名称：JOURNAL OF REPRODUCTIVE IMMUNOLOGY （ 影响因子：2.9； 五年影响因子：3.3 ）
ISSN： 0165-0378
年卷期： 2025 年 167 卷
页码：
收录情况： SCI
摘要： Active immunization against gonadotropin-releasing hormone (GnRH) affects the immune system by inhibiting testosterone production. Our previous study investigated the effects of GnRH immunization on thymic T-cell generation, migration, and colonization in peripheral immune organs. However, the mechanisms by which GnRH immunization influences B cell generation and the characteristics of B cell colonization in peripheral immune organs remain unclear. Herein, GnRH immunization enhanced B cell generation by reducing apoptosis. GnRH immunization did not markedly affect the cell cycle of bone marrow cells, B cell development-related signaling molecules, or the percentage of B cells in the blood, spleen, or inguinal lymph nodes. After testosterone supplementation in GnRH-immunocastrated rats, the generation of B cells in the bone marrow was significantly reduced, and the apoptosis of B cells was remarkably increased. Testosterone did not significantly affect the cell cycle of bone marrow cells or the proportion of B cells in the blood, spleen, or inguinal lymph nodes of the GnRHimmunocastrated rats. Overall, these results clarify the mechanisms related to B cell expansion in the bone marrow and the settlement characteristics of B cells in peripheral immune organs after GnRH immunization.
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