您好，欢迎访问西藏自治区农牧科学院 机构知识库！

Transcriptome analysis identified long non-coding RNAs involved in the adaption of yak to high-altitude environments

文献类型： 外文期刊

作者： Xin, Jin-Wei 1 ; Chai, Zhi-Xin 3 ; Zhang, Cheng-Fu 1 ; Yang, Yu-Mei 3 ; Zhang, Qiang 1 ; Zhu, Yong 1 ; Cao, Han-Wen 1 ; J 1 ;

作者机构： 1.State Key Lab Hulless Barley & Yak Germplasm Res, Lhasa, Peoples R China

2.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci & Vet, Lhasa, Peoples R China

3.Southwest Minzu Univ, Sichuan Prov & Minist Educ, Key Lab Qinghai Tibetan Plateau Anim Genet Resour, Chengdu, Peoples R China

关键词： adaption; bioinformatics; high altitude; long non-coding RNA; yak

期刊名称：ROYAL SOCIETY OPEN SCIENCE （ 影响因子：2.963； 五年影响因子：3.44 ）

ISSN： 2054-5703

年卷期： 2020 年 7 卷 9 期

页码：

收录情况： SCI

摘要： The mechanisms underlying yak adaptation to high-altitude environments have been investigated using various methods, but no report has focused on long non-coding RNA (lncRNA). In the present study, lncRNAs were screened from the gluteus transcriptomes of yak and their transcriptional levels were compared with those in Sanjiang cattle, Holstein cattle and Tibetan cattle. The potential target genes of the differentially expressed lncRNAs between species/strains were predicted using cis and trans models. Based on cis-regulated target genes, no KEGG pathway was significantly enriched. Based on trans-regulated target genes, 11 KEGG pathways in relation to energy metabolism and three KEGG pathways associated with muscle contraction were significantly enriched. Compared with cattle strains, transcriptional levels of acyl-CoA dehydrogenase, acyl-CoA-binding protein, 3-hydroxyacyl-CoA dehydrogenase were relatively higher and those of glyceraldehyde 3-phosphate dehydrogenase, phosphoglycerate mutase 1, pyruvate kinase and lactate/malate dehydrogenase were relatively lower in yak, suggesting that yaks activated fatty acid oxidation but inhibited glucose oxidation and glycolysis. Besides, NADH dehydrogenase and ATP synthase showed lower transcriptional levels in yak than in cattle, which might protect muscle tissues from deterioration caused by reactive oxygen species (ROS). Compared with cattle strains, the higher transcriptional level of glyoxalase in yak might contribute to dicarbonyl stress resistance. Voltage-dependent calcium channel/calcium release channel showed a lower level in yak than in cattle strains, which could reduce the Ca2+ influx and subsequently decrease the risk of hypertension. However, levels of EF-hand and myosin were higher in yak than in cattle strains, which might enhance the negative effects of reduced Ca2+ on muscle contraction. Overall, the present study identified lncRNAs and proposed their potential regulatory functions in yak.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：西藏自治区农牧科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台