文献类型： 外文期刊

作者： Hao, Baocheng ¹ ; Wang, Xinjian ² ; Ma, Xueqing ³ ; Jin, Yongming ² ; Fan, Wenguang ² ; Laba, Cidan ⁴ ; Wujin, Cuomu ⁴ ;

作者机构： 1.Chinese Acad Agr Sci, Key Lab New Anim Drug Project, Key Lab Vet Pharmaceut Dev, Lanzhou Inst Husb & Pharmaceut Sci,Minist Agr & R, Lanzhou 730050, Peoples R China

2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China

3.Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Natl Foot & Mouth Dis Reference Lab, 1 Xujiaping, Lanzhou 730046, Peoples R China

4.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci & Vet, Lhasa 850009, Peoples R China

关键词： Glycyrrhiza polysaccharide; Microcapsule; Wound healing

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2020 年 156 卷

页码：

收录情况： SCI

摘要： The extraction process of Glycyrrhiza soluble polysaccharide (GP) was optimized by RSM, a rat trauma model was established via longitudinal incision on the back skin. The effects of GP combined with microcapsule collagen on the repair of rat injury model were discussed at different levels, Based on the content of hydroxyproline at the whole animal level, the proliferation of granulation tissue stained by HE, the number of microvessels labeled by CD34, the production of collagen fibers stained by Masson, the level of phosphorylation of STAT3 protein and that of VEGF at protein level were investigated. The results showed that after the administration of GP combined with microcapsules, the content of hydroxyproline in granulation tissue increased, the proliferation of capillaries and fibroblasts in granulation tissue became active, and the number of microvessels in wound increased. The formation density of collagen fibers was uniform and orderly. GP combined with microcapsules could activate the expression of p-STAT3 and VEGI proteins and up-regulate the transcription level of VEGF mRNA and miRNA-21 genes. Furthermore, GP combined with microcapsules could accelerate wound healing and promote neovascularization. (C) 2020 Elsevier B.V. All rights reserved.