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Coping with extremes: the rumen transcriptome and microbiome co-regulate plateau adaptability of Xizang goat

文献类型： 外文期刊

作者： Pan, Cheng 1 ; Li, Haiyan 1 ; Mustafa, Shehr Bano 1 ; Renqing, Cuomu 2 ; Zhang, Zhenzhen 1 ; Li, Jingjing 1 ; Song, Tianzeng 2 ; Wang, Gaofu 4 ; Zhao, Wangsheng 1 ;

作者机构： 1.Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang 621000, Sichuan, Peoples R China

2.Xizang Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa 850009, Xizang, Peoples R China

3.Minist Agr & Rural Affairs, Key Lab Anim Genet & Breeding Tibetan Plateau, Lhasa 850009, Peoples R China

4.Chongqing Acad Anim Sci, Chongqing 402460, Rongchang, Peoples R China

关键词： Xizang goat; Plateau adaptability; Rumen microbiota; Transcriptome; Climate

期刊名称：BMC GENOMICS （ 影响因子：3.7； 五年影响因子：4.2 ）

ISSN： 1471-2164

年卷期： 2024 年 25 卷 1 期

页码：

收录情况： SCI

摘要： The interactions between the rumen microbiota and the host are crucial for the digestive and absorptive processes of ruminants, and they are heavily influenced by the climatic conditions of their habitat. Owing to the harsh conditions of the high-altitude habitat, little is known about how ruminants regulate the host transcriptome and the composition of their rumen microbiota. Using the model species of goats, we examined the variations in the rumen microbiota, transcriptome regulation, and climate of the environment between high altitude (Lhasa, Xizang; 3650 m) and low altitude (Chengdu, Sichuan, China; 500 m) goats. The results of 16 S rRNA sequencing revealed variations in the abundance, diversity, and composition of rumen microbiota. Papillibacter, Quinella, and Saccharofermentans were chosen as potential microbes for the adaptation of Xizang goats to the harsh climate of the plateau by the Spearman correlation study of climate and microbiota. Based on rumen transcriptome sequencing analysis, 244 genes were found to be differentially expressed between Xizang goats and low-altitude goats, with 127 genes showing up-regulation and 117 genes showing down-regulation. SLC26A9, GPX3, ARRDC4, and COX1 were identified as potential candidates for plateau adaptation in Xizang goats. Moreover, the metabolism of fatty acids, arachidonic acids, pathway involving cytokines and their receptors could be essential for adaptation to plateau hypoxia and cold endurance. The expression of GPX3, a gene linked to plateau acclimatization in Xizang goats, was linked to the abundance of Anaerovibrio, and the expression of SLC26A9 was linked to the quantity of Selenomonas, according to ruminal microbiota and host Spearman correlation analysis. Our findings imply that in order to adapt harsh plateau conditions, Xizang goats have evolved to maximize digestion and absorption as well as to have a rumen microbiota suitable for the composition of their diet.

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