Correlation analysis of four KRTAP gene polymorphisms and cashmere fiber diameters in two cashmere goat breeds
文献类型： 外文期刊
作者： Wua, Cuiling 1 ; Qin, Chongkai 4 ; Fu, Xuefeng 3 ; Zhao, Bingru 5 ; Wu, Yujiang 6 ; He, Junmin 2 ; Mao, Jingyi 1 ; Liu, Jing 1 ; Huang, Xixia 1 ; Tian, Kechuan 2 ;
作者机构： 1.Xinjiang Agr Univ, Coll Anim Sci, Urumqi 830000, Peoples R China
2.Shandong Acad Agr Sci, Inst Anim Sci & Vet Med, Jinan 250100, Peoples R China
3.Xinjiang Acad Anim Sci, Inst Anim Sci, Key Lab Genet Breeding & Reprod Xinjiang Wool Shee, Urumqi 830000, Peoples R China
4.Xinjiang Aksu Prefecture Anim Husb Technol Extens, Aksu 843000, Peoples R China
5.China Agr Univ, Coll Anim Sci & Technol, Lab Anim Genet Breeding and Reprod, Natl Engn Lab Anim Breeding,Minist Agr, Beijing 100083, Peoples R China
6.Tibet Acad Agr & Anim Husb Sci, Inst Anim Husb & Vet Med, Lhasa 850000, Peoples R China
关键词： Jiangnan cashmere goat; Tibetan cashmere goat; cashmere fiber diameter; KRTAPs
期刊名称：CANADIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：1.077； 五年影响因子：1.281 ）
ISSN： 0008-3984
年卷期：
页码：
收录情况： SCI
摘要： Fiber diameter, a quantitative trait, is controlled by minor effect polygenes. Keratin-associated proteins (KRTAPs) are an important part of hair, and their rich polymorphisms facilitate the mining of cashmere trait molecular markers. In this study, Jiangnan and Tibetan cashmere goats were taken as the research object; multiplex PCR and exome sequencing technology were used to identify the exon regional polymorphisms of cashmere goats KRTAP15-1, KRTAP13.1, KRTAP27-1, and KRTAP24-1. The effects of mutation sites on the fiber diameter of cashmere were analyzed by least square method. The results showed that there were 28 mutation sites in the four KRTAP genes in Jiangnan cashmere goats and Tibetan cashmere goat populations. Among them, the KRTAP13.1, KRTAP27-1, and KRTAP24-1 gene polymorphisms were found to be significantly related to the fiber diameter of Jiangnan cashmere goats. The exploration of molecular markers in this study will help to improve the fiber diameter of the down, while the identification of gene polymorphisms will provide original data for the utilization and protection of germplasm resources of cashmere goats.
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