文献类型： 外文期刊
作者： Kong, Zhiwei 1 ; Li, Bin 4 ; Zhou, Chuanshe 5 ; He, Qinghua 1 ; Zheng, Yuzhong 3 ; Tan, Zhiliang 5 ;
作者机构： 1.Shenzhen Univ, Coll Chem & Environm Engn, Dept Food Sci & Engn, Shenzhen, Peoples R China
2.Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices & Syst, Minist Educ & Guangdong Prov, Shenzhen, Peoples R China
3.Hanshan Nornal Univ, Sch Food Engn & Biotechnol, Chaozhou, Peoples R China
4.Tibet Autonomous Reg Acad Agr Sci, Inst Anim Husb & Vet, State Key Lab Hulless Barley & Yak Germplasm Reso, Lhasa, Peoples R China
5.Chinese Acad Sci, Inst Subtrop Agr, CAS Key Lab Agroecol Proc Subtrop Reg,Hunan Prov, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Changsha, Peoples R China
关键词： metabonomics; lipidomics; hypoxia; lipid metabolism; dairy cow
期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.471； 五年影响因子：3.821 ）
ISSN：
年卷期： 2021 年 8 卷
页码：
收录情况： SCI
摘要： Hypoxia exposure can cause a series of physiological and biochemical reactions in the organism and cells. Our previous studies found the milk fat rate increased significantly in hypoxic dairy cows, however, its specific metabolic mechanism is unclear. In this experiment, we explored and verified the mechanism of hypoxia adaptation based on the apparent and omics results of animal experiments and in vitro cell model. The results revealed that hypoxia exposure was associated with the elevation of AGPAT2-mediated glycerophospholipid metabolism. These intracellular metabolic disorders consequently led to the lipid disorders associated with apoptosis. Our findings update the existing understanding of increased adaptability of dairy cows exposure to hypoxia at the metabolic level.
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