A Bifidobacterium animalis subsp. lactis strain that can suppress Helicobacter pylori: isolation, in vitro and in vivo validation
文献类型： 外文期刊
作者： Zheng, Yanyi 1 ; Zhang, Silu 1 ; Zhang, Tengxun 2 ; Teng, Xin 2 ; Ling, Xueping 3 ; Li, Bin 4 ; Xiao, Guoxun 1 ; Huang, Song 2 ;
作者机构： 1.Shenhen Porshealth Bioengn Co Ltd, Wonderlab Innovat Ctr Healthcare, Shenzhen 518000, Peoples R China
2.Bluepha Co Ltd, Shenzhen 518000, Peoples R China
3.Xiamen Univ, Dept Chem & Biol Engn, Xiamen 361102, Peoples R China
4.Minist Agr & Rural Affairs, Inst Anim Husb & Vet, Tibet Acad Agr & Anim Husb Sci, Key Lab Anim Genet & Breeding Tibetan Plateau, Lhasa 850000, Peoples R China
5.Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China
关键词： H. pylori; probiotics; antibacterial activity; Bifidobacterium animalis; gastric inflammation
期刊名称：LETTERS IN APPLIED MICROBIOLOGY （ 影响因子：2.4； 五年影响因子：2.8 ）
ISSN： 0266-8254
年卷期： 2024 年 77 卷 1 期
页码：
收录情况： SCI
摘要： The administration of probiotics is an effective approach for treatment of Helicobacter pylori, which is associated with human gastrointestinal diseases and cancers. To explore more effective probiotics for H. pylori infection elimination, bacteria from infant feces were screened in this study. We successfully isolated the Bifidobacterium animalis subsp. lactis strains and evaluated its efficacy to inhibit H. pylori growth in vitro and in vivo. The results showed that a B. animalis strain (named BB18) sustained a high survival rate after incubation in gastric juice. The rapid urease test suggested that B. animalis BB18 reduced pathogen loads in H. pylori-infected Mongolian gerbils. Alleviation of H. pylori infection-induced gastric mucosa damage and decreased levels inflammatory cytokines were observed after the B. animalis BB18 administration. These findings demonstrated that B. animalis BB18 can inhibit H. pylori infection both in vitro and in vivo, suggesting its potential application for the prevention and eradication therapy of H. pylori infection.
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