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The differential proliferation and differentiation ability of skeletal muscle satellite cell in Boer and Nanjiang brown goats

文献类型： 外文期刊

作者： Zhao, Wei 1 ; Chen, Li 2 ; Zhong, Tao 1 ; Wang, Linjie 1 ; Guo, Jiazhong 1 ; Dong, Yao 1 ; Feng, Jing 3 ; Song, Tianzeng; 1 ;

作者机构： 1.Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Sichuan, Peoples R China

2.Guizhou Vocat Coll Agr, Guiyang 550000, Guizhou, Peoples R China

3.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa, Peoples R China

关键词： Differentiation; Goat; p38 MAPK; Proliferation; SMSCs

期刊名称：SMALL RUMINANT RESEARCH （ 影响因子：1.611； 五年影响因子：1.813 ）

ISSN： 0921-4488

年卷期： 2018 年 169 卷

页码：

收录情况： SCI

摘要： Here, for the first time, we analyzed skeletal muscle morphology in Boer and Nanjiang Brown (NJ) goats and then evaluated the differences in skeletal muscle satellite cells (SMSCs) proliferation and differentiation ability between the two breeds. Our results revealed that NJ goats had significantly more myofiber cells and a significantly smaller cross-section area compared with the Boer goats (P < 0.01). The Pax7, p38MAPK and MEF2A were more enriched in all three muscles of NJ goats, while the expressions of MyoG, TAK1, and MKK6 presented the opposite tendency. Additionally, MEF2C, MyoD and MKK3 exhibited somewhat muscle-type specific expression patterns. During proliferation there were significantly more SMSCs in NJ goats compared with Boer goats on days 3, 4, and 5 (P < 0.05). Moreover, the SMSCs fusion rate was higher in NJ goats than in Boer goats during the entire differentiation stage, though only significant on the 6th day (P < 0.05). The Pax7, MyoD, MKK3/6, p38MAPK, and MEF2C expression levels in NJ goat SMSCs were significantly higher than those in Boer goat SMSCs (P < 0.05). In conclusion, these findings indicate that SMSCs proliferation and differentiation potential were higher in NJ goats than in Boer goats, which possibly contribute to the meat-produce difference between the two breeds.

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