Active immunization against gonadotropin-releasing hormone affects thymic T cell production, migration, and colonization in male rat lymphoid tissue
文献类型： 外文期刊
作者： Li, Dong 1 ; Yao, Huan 1 ; Han, Xinfa 1 ; Cao, Xiaohan 1 ; Du, Xiaogang 1 ; Meng, Fengyan 1 ; Bu, Guixian 1 ; Kong, Fanli 1 ; Song, Tianzeng 1 ; Zeng, Xianyin 1 ;
作者机构： 1.Sichuan Agr Univ, Coll Life Sci, Yaan 625014, Sichuan, Peoples R China
2.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa 850009, Xizang, Peoples R China
3.130 Jinzhu West Rd, Lhasa, Xizang, Peoples R China
4.46 Xinkang Rd, Yaan, Sichuan, Peoples R China
关键词： GnRH immunization; Thymus; Recent thymic emigrants; CD4(+):CD8(+) T-cell ratio; Rats
期刊名称：JOURNAL OF REPRODUCTIVE IMMUNOLOGY （ 影响因子：3.4； 五年影响因子：3.9 ）
ISSN： 0165-0378
年卷期： 2023 年 159 卷
页码：
收录情况： SCI
摘要： Active immunization against gonadotropin-releasing hormone (GnRH) inhibits animal reproduction and has become a friendly alternative to surgical castration, which has been reported to affect the proportion of thymic T cell subpopulations. The effects of active immunization against GnRH on T cell migration from the thymus to the periphery and T cell distribution in lymphoid tissues remain unclear. Here, we showed that active immunization against GnRH increased thymic size and weight, enlarged the number of thymocytes, and enhanced CD4(+) recent thymic emigrants (RTEs) and CD8(+) RTEs migration to the blood and spleen. Active immunization against GnRH had no significant effect on naive CD4(+), naive CD8(+), CD4(+) memory/activated, or CD8(+) memory/activated T cells. In addition, active immunization against GnRH increased the proportion of CD3(+) T cells in the spleen and lymph nodes. The percentages of CD3(+)CD4(+) and CD3(+)CD8(+) T cells in the blood, spleen, and lymph nodes were not significantly affected by GnRH immunization. Overall, these results enhance our understanding of thymic T cell production, migration, and colonization in rat lymphoid tissues affected by GnRH immunization.
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