Inhibitory Effect and Potential Mechanism of Lactobacillus plantarum YE4 against Dipeptidyl Peptidase-4
文献类型： 外文期刊
作者： Sha, Jia 1 ; Song, Jiajia 1 ; Huang, Yechuan 2 ; Zhang, Yuhong 3 ; Wang, Hongwei 1 ; Zhang, Yu 1 ; Suo, Huayi 1 ;
作者机构： 1.Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China
2.Jingchu Univ Technol, Coll Bioengn, Jingmen 448000, Peoples R China
3.Tibet Acad Agr & Anim Husb Sci, Inst Food Sci & Technol, Lhasa 850000, Peoples R China
关键词： dipeptidyl peptidase-4; lactic acid bacteria; cell-free extracts; Caco-2 cells
期刊名称：FOODS （ 影响因子：5.561； 五年影响因子：5.94 ）
ISSN：
年卷期： 2022 年 11 卷 1 期
页码：
收录情况： SCI
摘要： This study investigated the inhibitory effect and mechanism of 12 LAB strains isolated from Chinese fermented foods on dipeptidyl peptidase-4 (DPP-4) using the Caco-2 cell model. The results showed that the inhibitory effect of cell-free extracts (CFEs) collected from each LAB strain on DPP-4 was higher than that of the cell-free excretory supernatants. The CFEs from Lactobacillus plantarum YE4 (YE4-CFE) exhibited the strongest DPP-4 inhibitory activity (24.33% inhibition). Furthermore, YE4-CFE altered the TNF and MAPK signaling pathways. Additionally, the YE4-CFE ultrafiltration fraction (<3 kDa) displayed a similar DPP-4 inhibitory activity to YE4-CFE. UHPLC-MS/MS identified 19 compounds with a relative proportion of more than 1% in the <3 kDa fraction, and adenine, acetylcholine, and L-phenylalanine were the top three substances in terms of proportion. Altogether, the inhibitory effect of YE4-CFE on DPP-4 was associated with the TNF and MAPK signaling pathways, and with the high proportion of adenine, acetylcholine, and L-phenylalanine.
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