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Qingke beta-glucan synergizes with a beta-glucan-utilizing Lactobacillus strain to relieve capsaicin-induced gastrointestinal injury in mice

文献类型： 外文期刊

作者： Tang, Tian 1 ; Song, Jiajia 1 ; Wang, Hongwei 1 ; Zhang, Yu 1 ; Xin, Jinwei 3 ; Suo, Huayi 1 ;

作者机构： 1.Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China

2.Chongqing Tianyou Dairy Co Ltd, Chongqing 401120, Peoples R China

3.State Key Lab Hulless Barley & Yak Germplasm Reso, Lhasa 850000, Peoples R China

关键词： beta-Glucan; Inflammation; Gastrointestinal injury

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）

ISSN： 0141-8130

年卷期： 2021 年 174 卷

页码：

收录情况： SCI

摘要： Capsaicin (CAP) is the main pungent component in capsicum fruits. Eating too much CAP leads to gastrointestinal injury. Previously, Qingke beta-glucan combined with beta-glucan-utilizing Lactobacillus plantarum S58 (LPS58) ameliorated high fat-diet-induced obesity, but their effects on CAP-induced gastrointestinal injury have not been investigated. Our results showed that Qingke beta-glucan reduced the CAP-induced gastrointestinal injury in Kunming mice. The serum levels of inflammatory cytokines and gastrointestinal hormones, and the localized inflammation and the expression of EGF, EGFR, VEGF, and ZO-1 in the gastrointestinal tissues in CAP-treated mice were partly restored by Qingke beta-glucan. The CAP-induced increase in the abundances of proinflammatory intestinal bacteria was also reduced by Qingke beta-glucan. More importantly, we found that these beneficial effects of Qingke beta-glucan were markedly enhanced by beta-glucan-utilizing LPS58 supplementation. Our study indicated that Qingke beta-glucan coupled with beta-glucan-utilizing LP.S58 relieved CAP-induced gastrointestinal injury. (C) 2021 Published by Elsevier B.V.

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