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Genetic signatures of high-altitude adaptation and geographic distribution in Tibetan sheep

文献类型： 外文期刊

作者： Liu, Jianbin 1 ; Yuan, Chao 1 ; Guo, Tingting 1 ; Wang, Fan 3 ; Zeng, Yufeng 1 ; Ding, Xuezhi 1 ; Lu, Zengkui 1 ; Renqing 1 ;

作者机构： 1.Chinese Acad Agr Sci, Lanzhou Inst Husb & Pharmaceut Sci, Jiangouyan St, Lanzhou, Peoples R China

2.Chinese Acad Agr Sci, Sheep Breeding Engn Technol Res Ctr, Jiangouyan St, Lanzhou, Peoples R China

3.China Agr Vet Biol Sci & Technol Co Ltd, Lanzhou, Peoples R China

4.Anim Husb Sci & Res Inst Gannan Tibet Autonomous, Hezuo, Peoples R China

5.Pizhou Agr & Rural Bur Jiangsu Prov, Pkwy St, Pizhou, Peoples R China

6.Pizhou Anim Hlth Supervis Inst Jiangsu Prov, Xizhong St, Pizhou, Peoples R China

7.Tibet Acad Agr & Anim Sci, Inst Livestock Res, Lhasa 850000, Peoples R China

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2020 年 10 卷 1 期

页码：

收录情况： SCI

摘要： Most sheep breeding programs designed for the tropics and sub-tropics have to take into account the impacts of environmental adaptive traits. However, the genetic mechanism regulating the multiple biological processes driving adaptive responses remains unclear. In this study, we applied a selective sweep analysis by combing 1% top values of F-st and ZHp on both altitude and geographic subpopulations (APS) in 636 indigenous Tibetan sheep breeds. Results show that 37 genes were identified within overlapped genomic regions regarding F-st significantly associated with APS. Out of the 37 genes, we found that 8, 3 and 6 genes at chromosomes (chr.) 13, 23 and 27, respectively, were identified in the genomic regions with 1% top values of ZHp. We further analyzed the INDEL variation of 6 genes at chr.27 (X chromosome) in APS together with corresponding orthologs of 6 genes in Capra, Pantholops, and Bos Taurus. We found that an INDEL was located within 5'UTR region of HAG1 gene. This INDEL of HAG1 was strongly associated with the variation of APS, which was further confirmed by qPCR. Sheep breeds carrying "C-INDEL" of HAG1 have significantly greater body weight, shear amount, corpuscular hemoglobin and globulin levels, but lower body height, than those carrying "CA-INDEL" of HAG1. We concluded that "C-INDEL" variation of HAG1 gene confers better hypoxia tolerance in the highlands of Tibetan and explains well geographic distributions in this population. These results contribute to our understanding of adaptive responses to altitude and geographic adaptation in Tibetan sheep populations and will help to guide future conservation programs for Tibetan sheep native to Qinghai-Tibetan Plateau.

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