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Determination of optimal dietary selenium levels by full expression of selenoproteins in various tissues of broilers from 1 to 21 d of age

文献类型： 外文期刊

作者： Liao, Xiudong 1 ; Liu, Guoqing 1 ; Sun, Guangming 1 ; Sun, Xiaoming 1 ; Liu, Tao 1 ; Lu, Lin 1 ; Zhang, Liyang 1 ; Zhang, Minhong 1 ; Guo, Yanli 3 ; Luo, Xugang 2 ;

作者机构： 1.Chinese Acad Agr Sci, Inst Anim Sci, Mineral Nutr Res Div, State Key Lab Anim Nutr, Beijing, Peoples R China

2.Yangzhou Univ, Coll Anim Sci & Technol, Poultry Mineral Nutr Lab, Yangzhou, Jiangsu, Peoples R China

3.Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou, Peoples R China

4.Case Western Reserve Univ, Biochem Dept, Cleveland, OH USA

5.State Key Lab Hulless Barley & Yak Germplasm Reso, Lhasa, Peoples R China

6.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci & Vet, Lhasa, Peoples R China

关键词： Selenium; Selenoprotein; Gene expression; Requirement; Broiler

期刊名称：ANIMAL NUTRITION （ 影响因子：5.285； 五年影响因子：7.059 ）

ISSN： 2405-6383

年卷期： 2021 年 7 卷 4 期

页码：

收录情况： SCI

摘要： The current NRC dietary selenium (Se) requirement (0.15 mg/kg) of broilers is primarily based on growth performance data reported in 1986. Our study aimed to determine optimal dietary Se levels of broilers fed a practical corn-soybean meal diet for the full expression of selenoproteins in various tissues. A total of 384 one-d-old male broilers (n = 8 replicates/diet) were fed a basal corn-soybean meal diet or the basal diet supplemented with 0.1, 0.2, 0.3, 0.4 or 0.5 mg Se/kg in the form of Na2SeO3 for 21 d. Regression analysis was conducted to evaluate the optimal dietary Se levels using broken-line, quadratic or asymptotic models. The activity of glutathione peroxidase (GPX) in the plasma, liver, kidney and pancreas, iodothyronine deiodinase (DIO) in the plasma, liver and pancreas, and thioredoxin reductase (Txnrd) in the liver and pancreas, the mRNA levels of Gpx1, Gpx4, Dio1, selenoprotein (Seleno) h, Selenop and Selenou in the liver, Gpx4, Dio1, Txnrd1, Txnrd2, Selenoh, Selenop and Selenou in the kidney, and Gpx1, Gpx4, Selenoh and Selenou in the pancreas, and the protein levels of GPX4 in the liver and kidney of broilers were influenced (P < 0.05) by added Se levels, and increased quadratically (P < 0.05) with the increase of added Se levels. The estimates of optimal dietary Se levels were 0.07 to 0.36 mg/kg based on the fitted broken-line, quadratic or asymptotic models (P < 0.001) of the aforementioned selenoprotein expression in the plasma, liver and kidney, and 0.09 to 0.46 mg/kg based on the fitted broken-line models (P < 0.001) of the aforementioned selenoprotein expression in the pancreas. The results indicate that the optimal dietary Se levels would be 0.36 mg/kg to support the full expression of selenoproteins in the plasma, liver and kidney, and 0.46 mg/kg to support the full expression of selenoproteins in the pancreas of broilers fed a practical corn-soybean meal diet from 1 to 21 d of age. (C) 2021 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.

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