Effects of Cryptosporidium parvum infection on intestinal fungal microbiota in yaks (Bos grunniens)
文献类型： 外文期刊
作者： Lu, Sijia 1 ; Zou, Wen 1 ; Chen, Xiushuang 1 ; Sun, Guangming 3 ; Cidan, Yangji 3 ; Almutairi, Mikhlid H. 4 ; Dunzhu, Luosang 3 ; Nazar, Mudassar 5 ; Mehmood, Khalid 6 ; Zhu, Yanbin 3 ; Basang, Wangdui 3 ; Li, Kun 1 ;
作者机构： 1.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Peoples R China
2.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Peoples R China
3.Tibet Acad Agr & Anim Husb Sci, Inst Anim Husb & Vet Med, Lhasa 850009, Peoples R China
4.King Saud Univ, Coll Sci, Zool Dept, POB 2455, Riyadh 11451, Saudi Arabia
5.Univ Agr Faisalabad, Subcampus, Burewala 61010, Pakistan
6.Islamia Univ Bahawalpur, Fac Vet & Anim Sci, Bahawalpur 63100, Pakistan
关键词： Cryptosporidium; Yaks; Fungi; Microbiota; Parasite; PCR
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.8； 五年影响因子：4.0 ）
ISSN： 0882-4010
年卷期： 2023 年 183 卷
页码：
收录情况： SCI
摘要： During the last decade, researchers had started to focus on the relationship between intestinal parasitic infection and variation of intestinal microflora. Cryptosporidium is a widely known opportunistic and zoonotic pathogen. Several studies have shown that Cryptosporidium infection has impact to alter the gut microflora. However, there are only few studies referring to the fungal microflora changes in response to Cryptosporidium infection in highland ruminants. Therefore, the present study was performed for exploring the alternations of intestinal fungal microbiota in yaks after exposure to Cryptosporidium infection. In present study, Amplicon sequencing of ITS regions was used to study the variations of fungal microflora in yaks. After filtering the raw data, over 45 000 and 62 000 clean data were obtained in uninfected and infected yaks, respectively. By using alpha diversity analysis, it was found that there is no significant difference in the richness and evenness when positive samples were compared with negative ones, whereas intestinal fungal communities in different taxa in yaks were changed. The results of present study depicted that 2-phyla and 21-genera in the infected animals had significantly (P < 0.05) changed. These genera were Septoria, Coniothyrium, Cleistothelebolus, Bensingtonia, Cystobasidium, Filobasidium, Coprotus, Carex, Blumeria, Coprinellus, Leucosporidium, Phialophora, Isolepis, Ascobolus, Thecaphora, Mortierella, Urocystis, Symmetrospora and Lasiobolus. In addition, we found variations in 28 enzymes suggesting that the function of microbiota was also affected. It is concluded that there are drastic changes in the fungal microflora and microbiota functions after exposure to Cryptosporidium infection in yak. Our results help to focus on the prompt way for the development of new therapies to control Cryptosporidiosis.
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