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Impacts of Population Size and Domestication Process on Genetic Diversity and Genetic Load in Genus Ovis

文献类型： 外文期刊

作者： Wang, Dongfeng 1 ; Salehian-Dehkordi, Hosein 3 ; Suo, Langda 4 ; Lv, Fenghua 3 ;

作者机构： 1.Chinese Acad Sci, Inst Zool, CAS Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China

2.Univ Chinese Acad Sci UCAS, Coll Life Sci, Beijing 100049, Peoples R China

3.China Agr Univ, Coll Anim Sci & Technol, Beijing 100193, Peoples R China

4.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa 850009, Peoples R China

关键词： Ovis; genetic diversity; genetic load; effective population; domestication; improvement

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 10 期

页码：

收录情况： SCI

摘要： In theoretical biology, a prevailing hypothesis posits a profound interconnection between effective population size (N-e), genetic diversity, inbreeding, and genetic load. The domestication and improvement processes are believed to be pivotal in diminishing genetic diversity while elevating levels of inbreeding and increasing genetic load. In this study, we performed a whole genome analysis to quantity genetic diversity, inbreeding, and genetic load across seven wild Ovis species and five domesticated sheep breeds. Our research demonstrates that the genetic load and diversity of species in the genus Ovis have no discernible impact on recent N-e, and three species within the subgenus Pachyceros tend to carry a higher genetic load and lower genetic diversity patterns. The results coincide with these species' dramatic decline in population sizes within the subgenus Pachyceros similar to 80-250 thousand years ago. European mouflon presented with the lowest N-e, lower genetic diversity, and higher individual inbreeding coefficient but a lower genetic load (missense and LoF). This suggests that the small N-e of European mouflon could reduce harmful mutations compared to other species within the genus Ovis. We showed lower genetic diversity in domesticated sheep than in Asiatic mouflon, but counterintuitive patterns of genetic load, i.e., lower weak genetic load (missense mutation) and no significant difference in strong genetic load (LoF mutation) between domestic sheep and Asiatic mouflon. These findings reveal that the "cost of domestication" during domestication and improvement processes reduced genetic diversity and purified weak genetic load more efficiently than wild species.

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