您好，欢迎访问西藏自治区农牧科学院 机构知识库！

Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers

文献类型： 外文期刊

作者： Guang-Xin, E. 1 ; Chen, Li-Peng 1 ; Zhou, Dong-Ke 1 ; Yang, Bai-Gao 1 ; Zhang, Jia-Hua 1 ; Zhao, Yong-Ju 1 ; Hong, Qio 1 ;

作者机构： 1.Southwest Univ, Coll Anim Sci & Technol, Chongqing Engn Res Ctr Herbivore Resource Protect, Chongqing Key Lab Forage & Herbivores, Chongqing 400716, Peoples R China

2.Yunnan Anim Sci & Vet Inst, Kunming 650224, Yunnan, Peoples R China

3.Chinese Acad Agr Sci CAAS, Inst Anim Sci, Beijing 100193, Peoples R China

4.Tibet Acad Agr & Anim Husb Sci TAAAS, State Key Lab Barley & Yak Germplasm Resources &, Lhasa 850002, Peoples R China

5.Chinese Acad Agr Sci CAAS, CAAS ILRI Joint Lab Livestock & Forage Genet Reso, Inst Anim Sci, Beijing 100193, Peoples R China

6.Int Livestock Res Inst ILRI, Livestock Genet Program, Nairobi 00100, Kenya

关键词： Major histocompatibility complex; Interspecific polymorphism; Diversity; Heterozygote advantage

期刊名称：MOLECULAR IMMUNOLOGY （ 影响因子：4.407； 五年影响因子：4.227 ）

ISSN： 0161-5890

年卷期： 2020 年 124 卷

页码：

收录情况： SCI

摘要： Major histocompatibility complex (MHC) genes are critical for disease resistance or susceptibility responsible for host-pathogen interactions determined mainly by extensive polymorphisms in the MHC genes. Here, we examined the diversity and phylogenetic pattern of MHC haplotypes reconstructed using three MHC-linked microsatellite markers in 55 populations of five Bovidae species and compared them with those based on neutral autosomal microsatellite markers (NAMs). Three-hundred-and-forty MHC haplotypes were identified in 1453 Bovidae individuals, suggesting significantly higher polymorphism and heterozygosity compared with those based on NAMs. The ambitious boundaries in population differentiation (phylogenetic network, pairwise F-ST and STRUCTURE analyses) within and between species assessed using the MHC haplotypes were different from those revealed by NAMs associated closely with speciation, geographical distribution, domestication and management histories. In addition, the mean FST was significantly correlated negatively with the number of observed alleles (N-A), observed (H-O) and expected (H-E) heterozygosity and polymorphism information content (PIC) (P< 0.05) in the MHC haplotype dataset while there was no correction of the mean FST estimates (P> 0.05) between the MHC haplotype and NAMs datasets. Analysis of molecular variance (AMOVA) revealed a lower percentage of total variance (PTV) between species/groups based on the MHC-linked microsatellites than NAMs. Therefore, it was inferred that individuals within populations accumulated as many MHC variants as possible to increase their heterozygosity and thus the survival rate of their affiliated populations and species, which eventually reduced population differentiation and thereby complicated their classification and phylogenetic relationship inference. In summary, host-pathogen coevolution and heterozygote advantage, rather than demographic history, act as key driving forces shaping the MHC diversity within the populations and determining the interspecific MHC diversity.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：西藏自治区农牧科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台