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Effect of immunization against GnRH on hypothalamic and testicular function in rams

文献类型： 外文期刊

作者： Han, Xingfa 1 ; Gu, Longjun 1 ; Xia, Chenyang 2 ; Feng, Jing 2 ; Cao, Xiaohan 1 ; Du, Xiaogang 1 ; Zeng, Xianyin 1 ; Song 1 ;

作者机构： 1.Sichuan Agr Univ, Isotope Res Lab, Yaan, Peoples R China

2.Tibet Acad Agr & Anim Husb Sci, Inst Anim Sci, Lhasa, Peoples R China

关键词： GnRH;Immunization;Reproductive function;Ram;Tibetan

期刊名称：THERIOGENOLOGY （ 影响因子：2.74； 五年影响因子：2.93 ）

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收录情况： SCI

摘要： The objective was to determine effects of active immunization against GnRH on reproductive function in Tibetan rams. Peripubertal Tibetan rams (n = 30) were randomly and equally allocated into three groups: control (no treatment); surgically castrated; or immunized against 100-mu g D-Lys6-GnRH-tandem-dimer peptide conjugated to ovalbumin in Specol adjuvant at 24 weeks of age (with a booster 8 weeks later). Blood samples (for antibody titers and hormone concentrations) were collected at 4-week intervals until rams were killed (40 weeks). Immunization triggered a good antibody response in all immunized rams (P < 0.01). Compared with intact controls, anti-GnRH immunization reduced (P < 0.01) serum concentrations of testosterone, inhibin A, LH, and FSH, and it induced testicular atrophy (suppression of spermatogenesis). Androstenone concentrations in fat tissues of GnRH-immunized rams were also rendered nondetectable (P < 0.001). Furthermore, mRNA expressions of GnRH receptor, LH-beta, and FSH-beta in the pituitary and of LH receptor, FSH receptor, and inhibin alpha and beta(A) subunits in the testes were decreased in immunized rams compared with intact controls (P < 0.05). This was apparently the first report that active immunization against GnRH-tandem-dimer-ovalbumin conjugate in Specol adjuvant was an effective alternative to surgical castration for Tibetan rams under practical Tibetan plateau conditions. (C) 2015 Elsevier Inc. All rights reserved.

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