您好，欢迎访问西藏自治区农牧科学院 机构知识库！

Intestine microbiota and SCFAs response in naturally Cryptosporidium-infected plateau yaks

文献类型： 外文期刊

作者： Dong, Hailong 1 ; Chen, Xiushuang 2 ; Zhao, Xiaoxiao 2 ; Zhao, Chenxi 2 ; Mehmood, Khalid 4 ; Kulyar, Muhammad Fakhar-e-Alam 5 ; Bhutta, Zeeshan Ahmad 6 ; Zeng, Jiangyong 7 ; Nawaz, Shah 8 ; Wu, Qingxia 1 ; Li, Kun 2 ;

作者机构： 1.Tibet Agr & Anim Husb Coll, Key Lab Clin Vet Med Tibet, Linzhi, Xizang, Peoples R China

2.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing, Peoples R China

3.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing, Peoples R China

4.Islamia Univ Bahawalpur, Fac Vet & Anim Sci, Dept Clin Med & Surg, Bahawalpur, Pakistan

5.Huazhong Agr Univ, Coll Vet Med, Wuhan, Peoples R China

6.Chungbuk Natl Univ, Coll Vet Med, Lab Biochem & Immunol, Cheongju, Chungbuk, South Korea

7.Tibet Acad Agr & Anim Husb Sci, Inst Anim Husb & Vet Med, Lhasa, Peoples R China

8.Univ Agr Faisalabad, Fac Vet Sci, Dept Anat, Faisalabad, Pakistan

关键词： Cryptosporidium; yaks; diarrhea; microbiota; SCFAs

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 影响因子：5.7； 五年影响因子：5.9 ）

ISSN： 2235-2988

年卷期： 2023 年 13 卷

页码：

收录情况： SCI

摘要： Diarrhea is a severe bovine disease, globally prevalent in farm animals with a decrease in milk production and a low fertility rate. Cryptosporidium spp. are important zoonotic agents of bovine diarrhea. However, little is known about microbiota and short-chain fatty acids (SCFAs) changes in yaks infected with Cryptosporidium spp. Therefore, we performed 16S rRNA sequencing and detected the concentrations of SCFAs in Cryptosporidium-infected yaks. Results showed that over 80,000 raw and 70,000 filtered sequences were prevalent in yak samples. Shannon (p<0.01) and Simpson (p<0.01) were both significantly higher in Cryptosporidium-infected yaks. A total of 1072 amplicon sequence variants were shared in healthy and infected yaks. There were 11 phyla and 58 genera that differ significantly between the two yak groups. A total of 235 enzymes with a significant difference in abundance (p<0.001) were found between healthy and infected yaks. KEGG L3 analysis discovered that the abundance of 43 pathways was significantly higher, while 49 pathways were significantly lower in Cryptosporidium-infected yaks. The concentration of acetic acid (p<0.05), propionic acid (p<0.05), isobutyric acid (p<0.05), butyric acid (p<0.05), and isovaleric acid was noticeably lower in infected yaks, respectively. The findings of the study revealed that Cryptosporidium infection causes gut dysbiosis and results in a significant drop in the SCFAs concentrations in yaks with severe diarrhea, which may give new insights regarding the prevention and treatment of diarrhea in livestock.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：西藏自治区农牧科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台