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Molecular Cloning and Function Characterization in Feeding of Neuropeptide Y in Gibel Carp, Carassius auratus gibelio

文献类型： 外文期刊

作者： Lei, Luo 1 ; Deng, Xingxing 1 ; Yuan, Dengyue 2 ; Zheng, Zonglin 1 ; Zhu, Chengke 1 ; Luo, Hui 1 ; Li, Baohai 3 ; Ye, Hua 1 ;

作者机构： 1.Southwest Univ, Coll Anim Sci, Chongqing 402460, Peoples R China

2.Neijiang Normal Univ, Coll Life Sci, Dept Aquaculture, Neijiang 641000, Sichuan, Peoples R China

3.Tibet Acad Agr & Anim Husb Sci, Lhasa 850002, Tibet, Peoples R China

关键词： Gibel carp; neuropeptide Y; Cloning; Fasting; Feeding

期刊名称：PAKISTAN JOURNAL OF ZOOLOGY （ 影响因子：0.831； 五年影响因子：0.768 ）

ISSN： 0030-9923

年卷期： 2019 年 51 卷 3 期

页码：

收录情况： SCI

摘要： To elucidate the mechanism of neuropeptide Y (npy) gene in feeding in gibel carp, we cloned and identified the npy cDNA sequence. Furthermore, we examined the npy mRNA distribution in 21 tissues and investigated the effect of its expression at different nutritional levels. Herein, we found that gibel carp npy has an Open Reading Frame (ORF) containing 291 bp. Moreover, the expression of npy was detected in all tested tissues, with the hypothalamus showing the highest expression in gibel carp. The npy mRNA expression in the hypothalamus significantly decreased 1 and 3 h after feeding (P < 0.01). Furthermore, its expression in the hypothalamus was significantly increased after fasting for 7 days and declined 2 days after refeeding (at 11-day and 14 -day; P < 0.01), suggesting that npy is an orexigenic peptide in gibel carp. In conclusion, these results indicated that npy is a conserved peptide within vertebrates and might exert orexigenic role in gibel carp.

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