文献类型： 外文期刊

作者： Xia, Chen ¹ ; Chen, Jian ¹ ; Deng, Jun-Lin ¹ ; Zhu, Yong-Qing ¹ ; Li, Wan-Yi ² ; Jie, Bu ³ ; Chen, Tian-Yuan ⁴ ;

作者机构： 1.Sichuan Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Funct Food Drug Labs, Chengdu 610066, Sichuan, Peoples R China

2.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650200, Yunnan, Peoples R China

3.Tibet Acad Agr & Anim Husb Sci, Lasa 850002, Tibet Province, Peoples R China

4.Univ Calif Berkeley, Dept Mol Cell Biol, Berkeley, CA 94720 USA

关键词： Maca; Lepidium meyenii; Macamide; Isolation; Identification; Cytotoxicity

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2018 年 25 卷

页码：

收录情况： SCI

摘要： Maca, Lepidium meyenii Walpers (Brassicaceae), contains secondary metabolites, including macamides, which possess many bioactive properties. Two new macamides, namely, N-benzyl-9-oxo-10E, 12E-octadecadienamide (3) and N-benzyl-9-oxo-10E, 12Z-octadecadienamide (4), were isolated from maca root. In addition, two fatty acid derivatives, 9-oxo-10E, 12E-octadecadienoic acid (1) and 9-oxo-10E, 12Z-octadecadienoic acid (2), were found for the first time from maca. The structures of compounds (3) and (4) were elucidated by spectrometric and spectroscopic methods including UV, IR, H-1 NMR, C-13 NMR, 2D NMR and HR ESI-MS experiments. The novel macamides exhibit inhibitory activity against the proliferation of the HT-29 cancer cell line with IC50 values of 12.8 mu mol/L (3) and 5.7 mu mol/L (4). The two compounds were inactive (IC50 > 50 mu mol/L) towards the proliferation of SGC7901, MCF7, NCI-H460 and HepG2 cancer cell lines.