Methylotrophic yeasts for chemicals production using methanol as substrate: Current status, challenges, and strategies
文献类型： 外文期刊
作者： Duan, Xiyu 1 ; Wang, Chong 2 ; Yang, Xiaona 2 ; Liu, Huhu 2 ; Lu, Xiangyang 2 ; Li, Changzhu 3 ; Li, Peiwang 3 ; Wang, Zhi 1 ; Tian, Yun 2 ;
作者机构： 1.Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China
2.Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China
3.Hunan Acad Forestry, State Key Lab Utilizat Woody Oil Resource, Changsha 410018, Hunan, Peoples R China
4.Yuelushan Lab, Changsha 410128, Hunan, Peoples R China
5.Tibet Acad Agr & Anim Husb Sci, Inst Agr Qual Stand & Testing, Lhasa 850000, Tibet, Peoples R China
关键词： Methylotrophic yeasts; Methanol; C1 substrate; Metabolic engineering; Green biomanufacturing
期刊名称：BIORESOURCE TECHNOLOGY （ 影响因子：9.0； 五年影响因子：9.5 ）
ISSN： 0960-8524
年卷期： 2025 年 434 卷
页码：
收录情况： SCI
摘要： Methanol, an inexpensive and renewable feedstock, has garnered significant attention in the green biomanufacturing industry. The bioconversion of methanol to chemicals offers a promising way to combat the food crisis and mitigate climate change. Methylotrophic yeasts, which are promising candidates, have a natural compartmentalized ability to utilize methanol, effectively reducing the toxic effects of methanol metabolism on cells. This review comprehensively summarizes the recent progress in the bioconversion of methanol for chemical production using methylotrophic yeasts. Furthermore, a series of feasible strategies are proposed to address the challenges of low utilization of methanol, cytotoxicity of methanol and its derivative formaldehyde, and oxidative stress. Finally, the future development directions of methylotrophic yeasts are outlined.
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