Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites
文献类型： 外文期刊
作者： Kong, Qinghui 1 ; Chen, Xiushuang 2 ; Liu, Yang 4 ; Ali, Farah 5 ; Idrees, Asif 6 ; Ataya, Farid Shokry 7 ; Shang, Zhenda 1 ; Li, Kun 2 ;
作者机构： 1.Tibet Agr & Anim Husb Coll, Key Lab Clin Vet Med Tibet, Linzhi 860000, Tibet, Peoples R China
2.Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Peoples R China
3.Nanjing Agr Univ, Coll Vet Med, MOE Joint Int Res Lab Anim Hlth & Food Safety, Nanjing 210095, Peoples R China
4.Tibet Acad Agr & Anim Husb Sci, Inst Anim Husb & Vet Med, Lhasa 850000, Peoples R China
5.Islamia Univ Bahawalpur, Fac Vet & Anim Sci, Bahawalpur 63100, Pakistan
6.Coll Vet & Anim Sci, KBCMA, Narowal, Pakistan
7.King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia
关键词： Diarrhea; Yak; Sodium acetate; Sodium butyrate; Microbiota; SCFAs
期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）
ISSN：
年卷期： 2024 年 10 卷 5 期
页码：
收录情况： SCI
摘要： Diarrhea is a severe issue in calves that causes fertility problems and economic issues worldwide. Sodium acetate/sodium butyrate (SA/SB) alleviates diarrhea in mice; however, little information is available about the preventive effect of SA/SB on diarrheic yak calves living on the Tibet plateau. Yak calves (n = 19) of age >= 4 months and weight 37 +/- 2 Kg were randomly divided into control (C, n = 10) and supplement groups (S, n = 9). Yaks belonging to the supplement group were given sodium butyrate (10 g/kg) and sodium acetate (5 g/kg) for 28 days, along with normal feed, seasonal grasses, pasture, and water. The blood and fecal samples from yak calves were collected for assessment of antioxidant capacity, inflammatory cytokines, microbiome, and short-chain fatty acids (SCFAs) concentration analysis. Results of this study revealed that a lower diarrhea rate, higher weight, and net weight gain were recorded in yaks belonging to group S supplemented with SA/SB. Similarly, increased antioxidant capacity with higher levels of T-AOC, SOD, and GSH-px and decreased inflammatory reactions by decreasing both TNF-alpha and IL-1 beta concentrations were recorded in yaks of group S. The concentration of SCFAs was significantly higher (p < 0.05) in yaks from group S than group C. Microbiome analysis revealed that 8 phyla and 54 genera were significantly different (p < 0.05) in both yak groups, with increased probiotics (Akkermansia, Oscillospira), SCFAs producing genera (Oscillospira, ASF356, Anaerosporobacter and Phascolarctobacterium), and decreased inflammatory related genus (Flavonifractor, Fournierella) and harmful bacteria (Oscillibacter, Achromobacter) in group S. In conclusion, the results demonstrated that SA and SB could decrease diarrhea rates in yak calves on the plateau via increasing antioxidant ability and SCFAs, while decreasing inflammatory responses in yaks by moderating gut microbiota. The current results provide new insights for the prevention and treatment of diarrhea in yaks.
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